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In addition, a variety of substances that are known to be toxic, carcinogenic, or disease-causing have been identified in vaping liquid solutions and aerosols, including delivery solvents, flavorings, carbonyl compounds, minor tobacco alkaloids, tobacco-specific nitrosamines, reactive oxygen species, metals, and other toxicants

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While most youth using e-cigarettes are dual users, up to a third of adolescent e-cigarette users have never smoked a conventional cigarette, indicating that some youth are starting use of the addictive drug nicotine with e-cigarettes

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