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The use of pesticides and other agrochemicals poses a risk to workers growing tobacco

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The total economic cost of smoking worldwide (derived from associated healthcare expenditures and productivity losses) is estimated at US$ 1.4 trillion, which is equivalent to 1.8% of the global annual GDP in 2012

Although Native Americans are said to have consumed tree tobacco and to have smoked the leaves for ceremonial and spiritual purposes, smoking tree tobacco induces vomiting, and ingestion causes seizures and even death