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A 2015 report from the Institute of Medicine found that raising the age for tobacco sales to 21 would have a substantial effect on public health and save lives. To date, 17 states and 500 local jurisdictions have raised smoking age to 21

Recessive mutants with defects in cutin synthesis, such as cd1 , cd2 , and cd3 , show significantly reduced cutin content, thinner exocarp, and increased fruit gloss (Isaacson et al., 2009)

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Antoniou GN, Iliopoulos D, Kalkouni R, et al