earliest use of tobacco North America's Smokers May Have Helped Launch the Agricultural Revolution Evolution of tobacco products: recent

In short-term use, these include impaired short-term memory, impaired motor coordination, risk of injury, e.g., driving, altered judgement, e.g., sexual behaviors leading to risk of STDs, paranoia, and psychosis (usually in higher doses)

Spontaneous nicotine withdrawal potentiates the effects of stress in rats

15 However, some studies found that in extreme cases of heavy exposure (long duration in an unventilated space) nonsmokers had positive tests for THC in oral fluid and blood up to three hours following the exposure

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Tobacco firms say they ban under 18s from hazardous work and only allow them to handle dry tobacco when there is no risk to health