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In contrast, smokers treated with nicotine nasal spray showed no difference in plasma nicotine concentration as a function of the rate of nicotine metabolism, consistent with the idea that nicotine taken in from the spray is titrated by the smoker to the desired effect

They also have white dots scattered along the margin

1 Nicotine is the primary addictive substance contained in commercial tobacco

"Very little is known about what happens with these when heated and inhaled for weeks, months or years." Key question #2: Are e-cigarettes safer than regular cigarettes

There is no rich or powerful compounding of flavors or tars