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The relationship between asbestos and lung cancer in general is governed by a near-linear dose-response relationship, with no clearly delineated threshold, but the gradient of the dose-response line is less steep than the analogous dose-response line between asbestos and pleural malignant mesothelioma

Indirectly, smoking can lead to secondary polycythemia due to increased carboxyhemoglobin levels, which reduces the oxygen-carrying capacity of the blood and results in tissue hypoxia [11, 12]

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To the best of our knowledge, the only study that investigated how nicotine affects TNPs demonstrates that exposure to nicotine ( in vivo ) dramatically down-regulates the expression of TNP1 and TNP2 (Table 2) [96]

H., Fiebelkorn, S., Johnson, M