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As for the more basic health side of things, everybody knows that routine smoking is very bad for you

(And for our fellow science nerds, the carbon and oxygen atoms of CO are connected by a triple bond.) The most common source of CO is the incomplete combustion of fuels such as gasoline, natural gas, heating oil, propane, kerosene, wood and charcoal

The lead SNP at the chr5q34 locus, rs1862416, is annotated to enhancer histone marks in brain (specifically, germinal matrix during fetal development and the developed prefrontal cortex, anterior caudate, and cingulate gyrus tissues) and several other tissues in HaploReg 43

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Detection windows also depend on the test: blood/saliva are typically shorter than urine, and hair can show exposure for weeks to months