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Although the mechanisms of appetite regulation by smoking are unknown, hypothalamic energy balance circuits were disturbed by cigarette smoke exposure as evidenced by the altered neuropeptide Y (NPY) concentration in the hypothalamic paraventricular nucleus, suggesting NPY signaling is involved in the appetite-suppressive effects of cigarette smoking [54]

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More than 80% of the worlds tobacco users live in low- to middle-income countries
The chemicals in cigarettes constrict blood vessels, reducing blood flow to the skin
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