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Research using PET imaging on smokers after overnight abstinence found that nicotine specifically reduced blood flow in the right amygdala while increasing flow to the thalamus, demonstrating how nicotine creates uneven cerebral circulation patterns

Tricyclic antidepressants have been reported to result in fewer negative side effects than MAOIs but more commonly adverse side effects than newer antidepressants

selection of pharmacotherapy most effective overall [#1] Varenicline +/- nicotine patch is generally preferred as front-line therapy (based on superiority in head-to-head trials as compared to bupropion or nicotine replacement)

Iacopino, Vincent (eds.)

But while it's now widely considered a given that being a habitual smoker is unhealthy, what about just a single puff from a cigarette