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Heavy smokers (12.4 8.4 cigarettes per day, n = 11) have found that e-cigarettes, especially those from the 1st generation, were unsatisfactory because delivery of nicotine was ineffective as compared with conventional cigarettes 22
However, it is not clear up yet whether DNA adducts are enough to cause tumorigenesis or the initiation of DNA adducts in the liver organism the initiator of carcinogenesis