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Interestingly, levels were significantly increased in PBECs from COPD patients when compared to non-smoking control PBECs, while a trend was visible when compared to PBECs from smokers, indicating a disease-related effect (Figure 5A)

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The tobacco life cycle is an overwhelmingly polluting and damaging process, with severe environmental consequences, including deforestation, the use of fossil fuels and the dumping of waste products into the natural environment including non-biodegradable butts millions of kilograms of which are discarded every year