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In both submerged cultured systems and airliquid interface (ALI) exposure models, 6-MN produces higher levels of reactive oxygen species (ROS) and enhanced cytotoxicity relative to nicotine, posing great risks to pulmonary diseases

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Cigar tobacco leaves are first aged for about a year and then fermented in a multi-step process that can take from 3 to 5 months
doi:10.1136/thorax.56.10.758 23
