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q , Total distance travelled by wild-type ( n = 6) and mutant ( n = 5) Tcf7l2 rats after daily injections of saline or nicotine (0.4 mg kg 1 ) (15 min pre-treatment time)

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19 Nicotine, the primary addictive component of cigarettes, has been reported to disrupt cellular metabolic processes, compromise genomic integrity, and accelerate the proliferation of transformed cells