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A different study attributed an improvement in respiratory functions of smokers who switch from traditional to electronic cigarettes [55]

This phenomenon, called sensitization, involves drug-induced brain changes that may underlie addiction and can be used to identify differences in susceptibility to the effects of drugs

It is sometimes called synthetic marijuana, but this is a misperception

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Because these pathways already exist, slight upregulation of some components in a shared ancestor may have enabled the origins of CAM in certain lineages (Brutigam et al., 2017)
