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Focus on high-potency users : The trial targets heavy users of cannabis concentrates, which can contain up to 90% THC and are strongly linked to dependence and withdrawal symptoms such as anxiety and sleep disruption

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In addition to TP53, EGFR mutations were found to significantly co-occur with CDKN2A and RB1 in LCNS, which have potential therapeutic and prognostic value, respectively [20]

This pattern supports the need for more targeted and context-specific interventions, particularly in urban environments and social settings where exposure is more likely to occur

The good performance of tobacco is related to the organization and productive efficiency of the sector