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CRF CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

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The CATS study (Cardiovascular Safety of Varenicline, Bupropion, and Nicotine Patch in Smokers), involving more than 8,000 smokers, found no evidence of an adverse effect on blood pressure and no increased risk of CV events in smokers treated with bupropion compared with NRT or placebo (54)

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