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Effects of cigarette smoke on immune response: chronic exposure to cigarette smoke impairs antigen-mediated signaling in T cells and depletes IP3-sensitive Ca 2+ stores

In 2011, results from the National Lung Screening Trial (NLST) demonstrated a 20% relative reduction in lung cancer mortality for individuals screened by low-dose helical computed tomography (LDCT) compared to standard chest radiography in a high-risk population of 53,454 current and former smokers aged 5574 years [150]
Cochrane Database of Systematic Reviews 2005, Issue 3
