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TJI articles confirmed the relevance of high sugar and low nicotine and also noted the desirability of FCVs large-sized leaf (see table 2).61 62 Precise application of fertiliser, removing unwanted stems, picking individual leaves as they ripen, careful post-harvest handling and flue-curing all contribute to achieving the low nicotine/high sugar balance.61 63 64 TJI demonstrated how these processes and characteristics increase costly agrochemical inputs, skilled labour requirements and the risk of failure.61 63 6568 This was confirmed by the Tobacco Association 1 and smallholders (see online supplemental Table S2 extracts 2.12.2)