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It has been demonstrated, for example, that cigarette-smoke condensate increases Sp1 expression and binding to DNA in lung epithelial cells ( de novo methylation of CpGs within these motifs during early embryogenesis ( hypoxia cigarette smoke contains carbon monoxide that binds to hemoglobin (competitively with oxygen) and thus decreases tissue oxygenation ( S -adenosylmethionine, a major biological methyl donor critical for DNA methylation processes ( FIGURE 2 Below we review studies investigating the alterations of DNA methylation associated with current and prenatal exposures to cigarette smoke

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Yingst JM, Veldheer S, Hrabovsky S, Sciamanna C, Foulds J

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DeFord Bailey Widely considered the first Black country music star, Bailey was the first African-American performer to appear on the Grand Ole Opry