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At the dynamic imaging level, the process by which death patterns switch over time during acute exacerbations (AECOPD) still lacks in vivo readouts, making it necessary to develop molecular imaging probes capable of distinguishing apoptosis, necroptosis, and pyroptosis to test hypotheses such as: the time series changes of the dominant PCD program during AECOPD progression have a quantifiable correspondence with neutrophilic inflammatory load, bacterial/viral load, and clinical outcomes, which can guide the optimal initiation timing of NLRP3 inhibitors, RIPK1/3 inhibitors, or Caspase-targeted drugs (313, 314)

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