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Furthermore, open EC systems that enable users to modify device power may facilitate compensation for lower nicotine concentrations, resulting in higher nicotine intake and enhanced nicotine reinforcement, which could increase dependence potential [102]

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Abbreviations: APESCGIT adverse physiological effects of smoking cessation on the gastrointestinal tract GIT gastrointestinal tract nAChRs nicotinic acetylcholine receptors Data sharing not applicable to this article as no datasets were generated or analyzed during the current study

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