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JAMA 296:4755 Jorenby DE, Hays JT, Rigotti NA, Azoulay S, Watsky EJ, Williams KE et al (2006) Efficacy of varenicline, an a4b2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial

Funding The authors would like to thank the Algerian Directorate General for Scientific Research and Technological Development (DGRSDT) and the Thematic Research Agency in Health Sciences (ATRSS) for the support of this research work via PNR project (33/DFPR/ATRSS)

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Dimensions: 2000 x 3000 px | 16.9 x 25.4 cm | 6.7 x 10 inches | 300dpi Date taken: 6 September 2012 Photographer: WENN More information: This image could have imperfections as its either historical or reportage.

Hindered Wound Healing: Smoking constricts blood vessels, reducing blood flow to the extraction site