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However, most studies that have looked at this association have not been able to disentangle whether this is a cause-and-effect relationship, and if so in which direction

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Cells were then blocked with 3% BSA at room temperature for 1 h followed by incubation with a primary antibody E-cadherin, ZO-1, Keap1 and Nrf2 (1:100 dilution) at 4 overnight

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