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Closed systems typically have higher nicotine content than open systems.[30] Thus, legislators could consider establishing a tiered system, where open refillable systems are taxed at a lower rate than closed systems, with different rates designed to equalize taxation and keep it neutral, not introduce unnecessary disparities

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they can also be turned into billboards, gas pump toppers, magnets, bumper stickers, and other materials

In cessation programs using nicotine replacement methods, such as the patch or gum, the nicotine does not seem to reduce craving as effectively for women as for men