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Most recently with the addition of immune checkpoint inhibitors such as nivolumab [70] or pembrolizumab [71] which prolongs disease-free survival after neoadjuvant chemoradiotherapy and surgery in patients with residual locally advanced esophageal squamous cell carcinoma, they are increasingly being incorporated into combined treatment strategies and are under investigation in both neoadjuvant and chemoradiation regimens

They both feature heating to reduce combustion effects and release nicotine without smoke

But a container of tobacco exposed to swinging temperatures does not alter its internal temperature uniformlysome parts of the contents becoming warmer than other parts of the contents

Arterial stiffness and carotid intima-media thickness in children exposed to smokeless tobacco in fetal life

DISCUSSION This study is one of the first comparative analyses of the respiratory, hematological, and inflammatory profiles among long-term users of cigarettes, shisha, and e-cigarettes in Saudi Arabia