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The process of fertilization is also a target of nicotine since one of its crucial events, acrosomal reaction, was shown to be significantly altered by nicotine [44]

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Of these, more than 7 million are due to direct tobacco use, while around 1.3 million non-smokers die from exposure to second-hand smoke

Nevertheless, the 3-4-fold increase in lung cancer risk due to vaping and smoking compared to smoking alone persisted after adjustment for each individual comorbidity