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All participants were age 59 to age 82 at the start of the study

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These stimuli result in increased antigen presentation, increased nitric oxide (NO) and reactive oxygen species (ROS) production, and drives heightened production of many inflammatory cytokines such as interleukin 12 (IL-12), interleukin 23 (IL-23), TNF-, interleukin 1 beta (IL-), interleukin 6 (IL- 6), type I IFN, and chemokines CXCL13, CXCL-5, CXCL810

Second, the semi-anonymous nature of phone counseling allows for candid discussion and faster progression of initial counseling sessions