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In contrast, smokers treated with nicotine nasal spray showed no difference in plasma nicotine concentration as a function of the rate of nicotine metabolism, consistent with the idea that nicotine taken in from the spray is titrated by the smoker to the desired effect

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[DOI] [PubMed] [Google Scholar] 94.Chen JK, Li ZP, Liu YZ, et al

According to the Nicotine Youth Tobacco Survey (NYTS), electronic nicotine delivery system (ENDS) products are the most commonly used tobacco product among youth in the US