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He referenced the four humours, a prevailing medical theory, to argue that tobacco disrupted bodily balance

Furthermore, smoke free legislations are also associated with a increased rate of smoking cessation [7]
Smoking cessation can be unassisted, which includes abrupt quitting (known as cold turkey) or a gradual reduction in tobacco smoking

The presence of cognitive deficits correlated with microglial activation and the increased expression of neuro-inflammatory cytokines such as IL1, TNF and IFN, in the hippocampus and the prefrontal cortex regions of the brain (153)
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