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while three studies had low samples (n = 3, Citation43 4, Citation42, 6, Citation43 ), after calculating the percentages with and without these three studies, gabapentin was successful 91.7% (11/12) of studies, and 88.9% (8/9) were successful if only studies with larger samples were included

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Cells exposed to e-cigarette smoke also showed increased microvascular permeability, elevated ICAM-1 levels (promoting leukocyte recruitment), and increased S100A8, a ligand that activates the RAGE receptor (Receptor for Advanced Glycation End Products), playing a role in transendothelial migration and cellular permeability [33]