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JAMA 1987;257:3373-6
Over time, repeated exposure to nicotine leads to changes in the brains chemistry, resulting in tolerance, dependence, and withdrawal symptoms when tobacco use is discontinued
Because the estimate had a wide confidence interval, we opted to begin the main study with an adaptive design (Chow & Chang, 2011)
Its no surprise that smoking was popular
It makes your body release lots of chemicals to give you a short-term buzz, but it doesnt change your sense of reality
