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[2] However, these laws kept changing throughout the 1950s, with Maryland repealing its age restrictions

Poisonous Substances/Tobacco Carcinogen: Cancer causing substance

4th edn, (John Wiley & Sons Hoboken, NJ, 2006)

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Further studies are needed to confirm the effects of smoking cessation on endothelial function using an appropriate study design, several smoking cessation methods, short- to long-term follow-up periods, different grades of smoking status, and diverse subjects including subjects with advanced atherosclerosis and healthy subjects in large clinical trials