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But their presence has declined, and China-based companies have grown rapidly, from 5 models in the daily top 50 at the beginning of 2025 to 20 in May 2026
Different TSNAs are formed from the reaction of alkaloids with nitrite 8 , and levels of available nitrite are influenced by nitrite-reducing bacteria that are known to be part of a variety of bacteria, or microbiota, associated with tobacco products 9
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