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Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016

10 Smoking seemed inevitable until it didnt The chart summarizes the history of smoking in the US (the development in other high-income countries was similar)

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E-cigarettes There may be a small to moderate benefit for cessation with e-cigarettes and little to no harms over the follow-up periods examined in RCTs we reviewed

COPD and multimorbidity: recognising and addressing a syndemic occurrence