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If we look at recent data from the Institute of Health Metrics and Evaluation (IHME), we should be alarmed

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95% CI: 1.021.19

Incidence rate differences were 4.68 (95% CI, 3.56-5.99) in the pooled cohort, 5.00 (95% CI, 3.17-7.25) in the original cohort, and 4.50 (95% CI, 3.20-6.10) in the offspring cohort
