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The heterogeneity assessment indicated considerable inconsistencies across the studies (P = 0.005, I 2 = 87.1)

According to the NCBI LiverTox database, nicotine itself "has not been associated with liver test abnormalities or with clinically apparent hepatotoxicity." However, some recent studies have identified potential links between nicotine use and non-alcoholic fatty liver disease (NAFLD)

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Inhibition of cytochrome P450 by ethambutol in human liver microsomes