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For example, Mishra and Sasmal have demonstrated the direct effect of chronic exposure to a MAO-B inhibitor on an increase in striatal dopamine levels ( Attention-Deficit/Hyperactivity Disorder Symptom Regulation and Nicotine Consumption Attention-deficit/hyperactivity disorder is associated with increased risk of smoking initiation at an early age, maintenance of smoking, and reduced propensity for smoking cessation for adults, possibly mediated by dopamine receptor activity patterns, in turn mediated by MAO-inhibitory contents and nicotine in cigarettes and e-cigarettes ( nicotine consumption in doses compatible with smoking, alleviates ADHD- related symptoms