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This indicated that nicotine had suppressed the expression and function of the Notch receptors

Benjamin Chaffee, a Professor at the University of California San Francisco School of Dentistry, told Healthline: "Theres not currently reliable evidence to indicate how common the condition is or the mechanisms causing it

So if you need yet another reason to stop smoking, this would be a big one

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The relationship between smoking and both CO and cotinine is modest (e.g., Swan et al., 1993), because the amount that is absorbed from smoking and the rate at which clearance occurs (as well as input from other sources [for CO] and rate of production [cotinine], Benowitz et al, 2002) are subject to variability