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Second, product use was limited to a single time-controlled use of an NP product on a single day, and as such we cannot infer whether nicotine pharmacokinetics will change over time following continued use or when individuals use NPs for shorter or longer time periods than the 60-min use period stipulated in this study protocol

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10.4049/jimmunol.1001603 [DOI] [PMC free article] [PubMed] [Google Scholar] 60
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