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Synthetic nicotine/ tobacco-free nicotine is an artificial replica of traditional nicotine derived from tobacco, but it is manufactured using chemicals that do not contain any tobacco plants

In sample S3, the notable genera included unclassified_Cyanobacteriales, Candida , and Enterobacter , whereas sample S4 presented three significantly different genera, namely Corynebacterium and Aerococcus

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"We want to keep tobacco prices as high as possible to reduce the attraction for kids and provide an incentive for people to quit," Lindblom said.

Its active ingredients, tar, nicotine, and nitrosamine, are potentially associated with oral cancer worldwide.[12,13] In the developed countries, smoking has been associated with over 85% deaths of all cancer deaths in men