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Most recently with the addition of immune checkpoint inhibitors such as nivolumab [70] or pembrolizumab [71] which prolongs disease-free survival after neoadjuvant chemoradiotherapy and surgery in patients with residual locally advanced esophageal squamous cell carcinoma, they are increasingly being incorporated into combined treatment strategies and are under investigation in both neoadjuvant and chemoradiation regimens

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This usually only happens if they are not fitted correctly

Vaping can be a delightful experience, offering a plethora of flavours and a smoke-free alternative to traditional cigarettes