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New frontiers of research investigating the molecular roles of FosB have been opened by epigenetic studies, and recent advances have illustrated the role of FosB acting on DNA and histones, truly as a molecular switch (34)

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2), the median values of the urinary nicotine levels (minimum-maximum) at the initial visit to the tobacco cessation clinic, and at 2 and 8 weeks later were 477.2 (36.32226.5) ng/mg creatinine, 8.7 (not detected (n.d.) 264.9) ng/mg creatinine, and 8.2 (1.9263.1) ng/mg creatinine