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"true wisdom only comes from pain" Thursday, March 01, 2007 Pee Wee Herman/Paul Ruebens In 1983,Pee Wee Herman was pretty much a stand up comic

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Restak described it metaphorically as "the basis for the withdrawal response in addiction when the receptors, deprived of their usual supply of addicting substance, 'cry out' like deserted lovers for the missing chemical." Without the chemical for a long enough period of time, the receptors are "down regulated." The circuits of the brain adapt to the presence of nicotine, whose structure mimics the structure of a naturally occurring brain chemical called acetylcholine , a substance that releases another substance called dopamine

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