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Given the large range of factors and agents in the tobacco regulatory environment (as illustrated in this chapter), ABMs developed by CTP or others will require consultation before development begins (and throughout the lifespan of the model) with relevant stakeholders, subject-matter experts, end users (e.g., decision makers), and the modeler to decide what domains and ABM characteristics would be appropriate for the intended purpose of the model (see Chapter 4)

Zhu et al .39 utilized 2-D gel electrophoresis and MALDI-TOF-MS analysis to screen the different expressed proteins in mice epididymis treated with tobacco smoking and identified 27 proteins which show significant alterations in protein profile