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Endothelial cells displayed characteristic features of pyroptosis in the aorta of nicotine-induced ApoE / mice Pyroptosis is uniquely dependent on the activation of caspase-1, which can process cytokines IL-1 and IL-18 into their active forms and then induce pyroptotic cell death

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00:02:46 Gina Corley So although these products are arguably safer than smoking cigarettes, we still want to let patients know this does not mean they are safe or healthy to use