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Indeed, there is evidence that 4 subunit nAChRs are sufficient for nicotine reinforcement, tolerance, and sensitization [22], and functional neuroimaging has revealed that experiential satiation from smoking closely scales to 42 occupancy [23]

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Preventive Services Task Force recommends annual low-dose CT screening in adults between the ages of 55 and 80 who have a 30 pack-year smoking history meaning that they have smoked the equivalent of one pack a day for 30 years, two packs per day for 15 years, and so on