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Mitigation strategies might include prescription requirements for higher-dose products, outright prohibition (as in Singapore, Australia, and Brunei Darussalam), and the classification of synthetic nicotine pouches as pharmaceutical or drug products rather than traditional tobacco products

Clonidine works through the brain and is often reserved for resistant hypertension or withdrawal-related symptoms, while propranolol acts on the heart and is commonly chosen when blood pressure control is needed alongside migraine prevention, anxiety symptoms, or heart conditions

The cigarette brand with the highest HI was C6 (1108.35), and the cigarette brand with the least HI was C2 with a value of 52.36 (Table 6)

Generally, for wage earners a certain amount of tax liability is withheld in payroll taxes throughout the year, which employers then submit to DRS

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