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Description
Wtp53 recognizes and binds to DNA response elements (RE), then recruits TFs, histone acetyltransferases (HATs) such as p300, chromatin remodeling complexes (CRCs) such as SWI and SNF that bind to acetylated histones [21, 55], and RNA polymerase II, which binds to open promoters to form the pre-initiation complex (Fig
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The acetylation of histones is widespread in eukaryotic cells, and most lysine residues on histones H3 and H4 are continuously acetylated during the whole mitotic period of mammalian somatic cells
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Toxicol Lett
