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Tobacco is addictive largely due to one of its active substances nicotine

Cholesterol plays a role in cell creation, hormone production, and food digestion

While there is currently no limit on the level of nicotine exposure that applies to every person who can become addicted, this begs the question of what level of nicotine reduction can prevent smokers from becoming addicted and what level of nicotine reduction can help established smokers readily control or quit their use

Here are the policies from some of the UK and Ireland's largest airlines: Ryanair - You are allowed to take the e-cigarette on board but you must not use this or any other form of cigarette on board EasyJet - You can take e-cigarettes in your hand luggage, but you cannot use them on the plane

Customised search strings were created and employed to locate relevant studies, the details of which are provided in Supplementary Material