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Van Gogh Museum

The tobacco "powder" or snuff became known as "Santacroce powder" or "santa polvere," that is, "holy powder." Pope Pius IV tasked Cistercian monks with growing tobacco in the Lazio region in the 16th century, and other monastic communities started growing the crop in other regions in Italy

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For cohort studies, we utilized the Newcastle-Ottawa Quality Assessment Scale for quantitative analysis, the Newcastle-Ottawa Scale was developed to assess the quality of nonrandomized studies with its design, content and ease of use directed to the task of incorporating the quality assessments in the interpretation of meta-analytic results (Supplementary material 1)